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Choice of preparations by animal species

Melvet

Suitable for:
horse cow pig dog cat

Melvet

Melvet

Solution for injections

 

Composition

1 ml of the drug contains: meloxicam 5 mg

 

Description

Liquid of light yellow color, clear

 

Pharmacological properties

Meloxicam — non-steroid anti-inflammatory agent of the oxicam class with analgesic and antipyretic action. The mechanism of action is based on the reduction of biosynthesis of prostaglandins, which are inflammatory mediators, due to inhibition of the enzymatic activity of COX-2. Partially influences COX-1, therefore reduces the risk of side effects. 
It has pronounced chondroprotective properties and, with long-term use, does not inhibit bone metabolism, and can therefore be used to treat diseases of the musculoskeletal system. In addition, it does not affect the gestation process in cows.

After subcutaneous, intramuscular or intravenous administration is completely absorbed, the relative bioavailability is 89-99%.
The maximum concentration in the blood is reached in 1-5 hours. Has a high degree of binding to proteins, preferably albumin (99%). After penetration into synovial fluid, the concentration becomes twice less than in plasma.
 
Metabolised by enzymes of the liver and excreted in urine and feces, partly in milk. The average half-life is approximately 20 hours. The total plasma clearance is an average of 8 ml / minute.
 

 

Indications

Treatment of animals in diseases:

  • cattle — acute and chronic diseases of the musculoskeletal system (traumatic edema, arthritis, arthrosis, bursitis, tendinitis, tendovaginitis, laminitis, pododermatitis, purulent-necrotic process in hooves in combination with antibacterial agents), acute respiratory infections, mastitis (in combination with antibiotic therapy), to reduce pain during dehorning of calves in combination with anesthesia of horn’s nerve.
  • pigs — acute and chronic diseases of the musculoskeletal system (laminitis, arthritis, myositis), after-farrowing sepsis, syndrome metritis-mastitis-agalaxia combined with antibiotic therapy;
  • horses — acute and chronic diseases of the musculoskeletal system (traumatic edema, arthritis, arthrosis, bursitis, tendinitis, tendovaginitis, laminitis, pododermatitis, purulent-necrotic process in hooves in combination with antibacterial agents), colic;
  • dogs, cats — acute and chronic diseases of the musculoskeletal system (injury, stretching of the ligaments and tendons, osteoarthritis, chronic degenerative joint disease etc. ), relief of postoperative pain.

 

Contraindications


Do not administer to animals with high sensitivity to the active substances of the drug, ulcer of the stomach and duodenum, hemorrhagic syndrome, severe nephritic or hepatic insufficiency. Do not administer to calves of up to 1 week, horses up to 6 weeks old, sheep up to 2 weeks old, dogs up to 6 weeks. Do not apply to pregnant and lactating mares, pregnant and lactating female cats and dogs.

Do not use at the same time with other non-steroidal anti-inflammatory drugs, corticosteroids and anticoagulants.

 

Route of administration and dosage

 

Species

Dose, ml / 10 kg body weight

Meloxicam, ml/ 1 kg of body weight

Route of administration

Cattle

1

0,5

Intravenous or intramuscularly, once, injection more than 20 ml should be divided and administered over different injections sites

Pigs

0,8

0,4

Intramuscularly, once, if needed repeat in 24 hours

Horses

1,2

0,6

Intravenous, one time

Dogs

0,4

0,2

Subcutaneously, intravenous, one time

Cats

0,4

0,2

Subcutaneously, one time

 

Warning

Do not mix with other drugs in one syringe.
After the subcutaneous application temporary swelling of the injection site may occur. If the animal is high-sensitive to the drug, the allergic reaction may occur (rash, urticaria, anaphylactic shock.
In case of any side effect, the drug should be stopped and reported to the veterinarians. Do not use the drug in animals with severe dehydration, hypovolemia and hypotonia, which need parenteral rehydration, because there is a potential risk of nephrotoxicity.
After the last administration of the drug, the slaughter of cattle for meat is allowed in 15 days, pigs and horses - in 5 days, milk can be used for human consumption in 5 days. Meat and milk, obtained earlier than the specified date, are disposed of or fed to unproductive animals, depending on the conclusion of the veterinarian.

 

Packaging

Glass vials of 10, 50 ml.

 

Storage conditions

In a dry dark place at the temperature from +8 to +25 °С.

After opening the vial, keep the drug in the refrigerator and use within 28 days

 

Shelf life

3 years.