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Choice of preparations by animal species

Imcar-120

Suitable for:

horse cow goat sheep

dog

сamel

Imcar-120

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Imcar-120

solution for injection

 

Composition

1 ml of the product contains:

imidocarb dipropionate — 120 mg

 

Description

Clear sterile liquid of yellowish color.

 

Pharmacological properties

The active ingredient of the product, imidocarb dipropionate is a derivative of carbanilide, provides wide spectrum of antiprotozoal action against agents of hemosporidial infections in case of monoinfection or mixed invasion Babesia bovis, B. ovis, B. bigemina, B. colchica, B. equi, B. divergens, B. canis, B. caballiTheileria annulata, T. sergenti, T. mutans, T. orientalis, T. ovis, T. recondita, T. hirci, T. tarandirangiferis, rickettsia of anaplasma genus

 Anaplasma marginale, A. centrale, A. ovis, A. phagocytophilum and ehrlichia Ehrlichia canis, E. chaffeensis

Mechanism of antiprotozoal action of imidocarb is based on inhibition of aerobic metabolism of glucose and synthesis of pyroplasmides DNA that subsequently leads to their destruction.

After parenteral administration, the imidocarb is rapidly absorbed from the injection site and, with blood flow, penetrates to most organs and tissues of the body. At the same time, its maximum concentration in the blood is formed during the first 1-2 hours, and is kept at the pyroplasmostatic level for 4-6 weeks. Imidocarb accumulates mainly in the kidneys and liver. Over time, it is excreted from the body, mostly with urine.

In terms of exposure to the animal organism Imidocarb dipropionate refers to moderately hazardous agents (3rd class of toxicity).

 

Indications

The medicinal product is indicated for treatment and prevention: artiodactyls ruminants (cattle, buffaloes, sheep, goats, zebu, mouflons, fallow deers, camels) for babesiosis, theileriasis, anaplasmosisand its mixed invasions; solidungulates (horses, mules, donkeys) for babesiosis, nuttalliosis, anaplasmosis and its mixed invasions; dogs for acute, chronic and subclinical babesiosis, mixed invasions.

Babesiosis chemoprophylaxis — introduction of the drug immediately after discovery of the tick and to animals from the risk group (hunting dogs).

 

Contraindications

Do not administer to animals sensitive to the active ingredient of the drug.
Do not use simultaneously with organochlorine and organophosphorus compounds, as well as with cholinesterase-inhibiting drugs.

Do not use the drug within 4 weeks after vaccination with live vaccine against babesiosis or anaplasmosis.

 

Dosage and routes of administration

Shake well before use.

Treatment and preventive care:

• Cattle, buffaloes, zebu, camels (subcutaneously, once)

 – babesiosis — 2 ml per 100 kg of body weight;

 – anaplasmosis — 2.5 ml per 100 kg body weight;

 – mixed invasions — 2.5 ml per 100 kg of body weight;

 – prophylactic dose — 2 ml per 100 kg of body weight.

• Sheep, goats, mouflons, fallow deers (intramuscularly once): babesiosis, anaplasmosis — 0.2 ml per 10 kg body weight.

• Horses, mules, donkeys (intramuscularly):

 – Babesia caballi — 2 ml per 100 kg of body weight, two injections with 24 hours interval;

 – Babesia equi — 3 ml per 100 kg of body weight, course of 4 injections, with 3-days interval.

• Dogs (subcutaneously, once): babesiosis — 0.3-0.5 ml per 10 kg of body weight, if necessary repeat in 14 days in a dose of 0.2 ml per 10 kg of body weight.

If blood-parasitic diseases are detected in animals which are kept in a group, Imcar-120 is administered to the entire population in a preventive dose, and the same doses are repeated: for cattle — in 6 weeks, for other animals — in 4 weeks.

 

Warnings

In recommended doses the product does not have a locally irritating effect, or cumulative, embryotoxic and mutagenic properties.

However, with massive death of blood parasites and erythrocyte destruction, the intoxication may develop. In such cases intensive therapy with the introduction of infusion dosage forms, hepatoprotectors, symptomatic and antihistamines is required.

Due to possible pain reaction do not administer into one injection site more than 10 ml of the drug for large animals, and more than 2 ml — for small animals.

Administration of antihistaminic agents is reasonable before the injection for the animals with clinical signs of babesiosis.

Slaughter of cattle for meat is allowed in 110 days, consumption of cow milk — in 7 days after the drug administration. Meat obtained before the specified period is fed to carnivores, milk after boiling can be fed to animals.

Milk of milking sheep after at least one administration of the drug, is forbidden for human consumption.

 

Package

Dark glass bottles vials of 10, 50 ml.

 

Storage

Store in a dry, well-ventilated place, protected from direct sunlight, separately from food and feed at a temperature between from +5 °C to +25 °C.

Opened vial should be kept in a refrigerator and used within 30 days.

 

Shelf life

2 years