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Choice of preparations by animal species


Suitable for:

dog cat

fur-bearing animals


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solution for external use



1 ml of the product contains:

fipronil — 100 mg

S-methoprene — 90 mg



Transparent liquid of yellowish color or colorless.


Pharmacological properties

Fipren — combined topical insectoacaricide, acts on fleas Ctenocephalides spp. at all development stages, louse Felicola subrostratus, Trichodectes canis, ixodic ticks Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Ixodes holocyclus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata, Haemaphysalis leachi, Amblyomma americanum, mosquitos Aedes aegypti, mites Sarcoptes scabiei var. canis, other ectoparasites affecting dogs, cats, ferrets.

Fipronil belongs to the insecto-acaracides of the phenylpyrazole group. It blocks selectively action of GABA chlorine-ion channels in nerve cells membranes of arthropods, and leads to disorder of nerve impulse transmission, convulsion and death of ectoparasites

S-methoprene is an analogue of the juvenile hormone, which acts as a regulator of insect growth and suppresses their growth and morphological development in the stages of the egg, larva and pupae due to antagonism with the ecdysone responsible for the growth and development of the larva. The ovocidal effect of S-methoprene appears as a result of direct penetration into the shell of eggs.

After a spot application to the skin, fipronil is slowly absorbed (up to 11%) until a lowest plasma concentration (Cmax) of about 35 ng/ml fipronil and 55 ng/ml of its main extensive metabolite fipronil-sulfone. The maximum concentration of fipronil in the blood plasma is achieved slowly (after about 100 hours) and decreases slowly (half-life is more than 150 hours).

Concentrations of S-metoprene in blood plasma after the skin application is below the limit of their quantification (20 ng/ml).

S-methoprene and fipronil together with its metabolite fipronil-sulphone are well distributed in animal wool within 24 hours after application. The concentration in the wool decreases over time, but the drug is detected even in 60 days after application.

Ectoparasites die mainly due to contact with the drug: fleas — within 24 hours, mites and lice — within 48 hours. The drug acts effectively against fleas at all stages of their development for 8 weeks, against ticks — for a minimum of 4 weeks after application.

Fipren refers to low-toxic substances for warm-blooded animals and at recommended doses does not give skin irritant, resorptive-toxic, embryotoxic and teratogenic effects.



Treatment and preventive care of myiasis in dogs, cats, ferrets caused by fleas, ticks, lice, louse; acariasis caused by Parasitiformes and Sarcoptes canis.



Do not administer to animals sensitive to the active ingredients of the drug, affected by infective diseases, weak or emaciated animals, puppies or kittens up to 8 weeks age, dogs up to 2 kg of body weight, ferrets up to 6 months old, productive animals.

Do not administer simultaneously with insectoacaricides.


Administration and dosage

The drug is applied by dropping pipette directly on clean dry skin at the upper back area of an animal to prevent licking off. The doses are indicated in the table.


Animal species and body weight, kg

Dose per an animal, ml

Unit dose of the active ingredients per an animal, ml




























Cats, ferrets:





For dogs over 60 kg the dose is calculated as 0.067 ml per 1 kg of body weight.

Avoid contact with water (rain, bath) after the product is applied.

Next treatment can be carried out at least 4 weeks later.



The general hygiene and safety rules adopted for working with veterinary drugs should be observed when working with the product. The animals are treated with using of rubber gloves. After processing, wash your hands thoroughly with warm water and soap. If the product gets on the skin, mucous membranes or eyes, rinse them with plenty of running water.

Within 24 hours after applying the drug, the animal's coat may be oily or glued. At this time, it is prohibited to pat the pets, sleep with them, allow children to play with the pets. Sometimes mild itching, hair loss, redness of the skin may occur on the sites of the product’s application. In cases of increased individual sensitivity and the appearance of allergic reactions, the drug should be washed off with water and detergent and, if necessary, antihistamines are prescribed.



PE pipettes of 0.5 or 1 ml (4 pcs in a carton box).


Storage conditions

Keep in the original package, in a dry place, protected from direct sunlight, out of children’s and animals’ reach, far from heating devices, separately from food and feed, at a temperature from +2 °С to +30 °С.


Shelf life

2 years.