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Choice of preparations by animal species

Ciflodex

Suitable for:

dog cat

Ciflodex

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Ciflodex

suspension, drops for eyes and ears

 

Composition

1 ml contains:

ciprofloxacin hypochloride — 4.5 mg

dexamethasone sodium phosphate — 1 mg

 

Description

White suspension.

 

Pharmacological properties

Combined chemotherapeutic agent, combines broad-spectrum antibiotic from the group of fluoroquinolones (ciprofloxacin) and glucocorticosteroid (dexamethasone), has antibacterial, anti-inflammatory, antiallergic and desensitizing properties.

Ciprofloxacin acts bactericides by inhibiting DNA gyrase and suppressing synthesis of bacterial DNA. Active against gram-negative microorganisms during rest and splitting — Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Vibrio spp., Campylobacter spp., Hafnia spp., Providencia stuartii, Haemophilus spp., Pasteurella multocida, Pseudomonas spp., Gardnerella spp., Neisseria spp., Moraxella catarrhalis, Acinetobacter spp., Brucella spp., gram-positive microorganisms in splitting process — Staphylococcus spp., Streptococcus pyogenes, Streptococcus agalactiae, Соrynebacterium diphtheriae, Listeria monocytogenes and other pathogens — Chlamydia spp., Mycoplasma spp., Mycobacterium spp.

Well absorbed, after 60 minutes its concentration in tear fluid is 4.98 μg/ml, and in fluid of the anterior chamber of the eye — 2.59 μg/ml. Half-life from the anterior chamber of the eye is 2 hours. When instilled in an eye, the concentration of ciprofloxacin in blood does not exceed 2.5 ng/ml, when instilled in ears — the maximum concentration in blood is reached after 15-90 minutes and is approximately 0.1% of the concentration of ciprofloxacin administered orally at a dose of 250 mg.

Dexamethasone is a synthetic fluorinated glucocorticosteroid with anti-inflammatory, antiallergic and antiproliferative action. Reduces the permeability and proliferation of capillaries, local exudation, cellular infiltration, phagocytic activity, collagen deposition and fibroblast activity, inhibits the formation of scar tissue and inflammation. Anti-inflammatory effect after instillation lasts 4-8 hours. With topical application, systemic absorption is low. After instillation into eyes, dexamethasone penetrates well into the epithelium of the cornea, conjunctival cells and into the fluid in the anterior chamber of the eye, its maximum concentration of 30 ng/ml is achieved after 2 hours, the elimination half-life is 3 hours. When used in ears, the maximum concentration in blood is reached after 15-90 minutes and is approximately 14% of the concentration of dexamethasone administered orally in a dose of 5 mg.

 

Indications

It is indicated for the treatment of dogs, cats, small exotic and decorative animals (fancy rabbits, hamsters, rats, mice, guinea pigs, parrots, repltiles) in case of acute and chronic infectious and inflammatory diseases of eyes and ears of bacterial, chemical or traumatic origin, including:

• conjunctivitis, blepharitis, keratitis, keratoconjunctivitis, iridits, iridocyclitis, ulcer and erosion of eye cornea, diseases of the eye after the injury or the ingress of foreign bodies or corrosive compounds, as well as during preoperative and postoperative periods;

• otitis, otorrhea, including those caused by outside interference.

 

Contraindications

Do not administer to animals with hypersensitivity to the active ingredients of the drug. Do not use for viral and fungal lesions of eyes and ears, along with non-steroidal anti-inflammatory drugs, theophylline, amphotericin and other drugs that excrete calcium, do not administer in the day of vaccination.

 

Administration and dosage

The drug is dripped into the conjunctival sac in the amount of 1-2 drops 2-4 times a day (in the complicated cases it is recommended to drip 1-2 drops every 2-3 hours), or into the auditory canal 1-4 drops depending on the weight of the animal 2-3 times per day.

If there is a significant purulent or muco-purulent discharge, pre-hygienic treatment of the eyes or ears is carried out: drip 3-4 drops of the drug and remove the discharge by sterile gauze pad. After this drip 1-2 drops of the drug and conduct the appropriate course of treatment.

Duration of treatment is 5-10 days until full recovery.

 

Warning

When dripped into the eyes, local irritation, itching, watery eyes may appear; rarely — allergic reactions, and in case of long-term use — secondary glaucoma may develop, as well as steroid cataract.

 

Packaging

Polymer vials with dropper of 10 ml (1 pc in a cardboard box).

 

Storage

Store in a dry, dark place, away from children at the temperature from +10 °C to +25 °C.

Shelf life after first opening (selection) is 30 days.

 

Shelf life

2 years.