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Choice of preparations by animal species


Suitable for:



Effective anti-metritis intrauterine product:
• wide spectrum of antibacterial action
• effective treatment of metritis — up to 95%
• active in aerobic and anaerobic conditions
• does not disturb the mechanisms of endometrial protection 

Not excreted with milk
Handy hygienic packaging


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suspension for intrauterine administration



19 g (1 syringe-tube) contain:

cefapirin benzathine — 640 mg (equal to 500 mg of cefapirin)



Liquid of white or cream color, with specific smell.


Pharmacological properties

Cefapirin has a wide range of action on Gram-positive and Gram-negative bacteria Arcanobacterium pyogenes Staphylococcus spp., Streptococcus pyogenes, Streptococcus dysgalactiae, Streptococcus uberis, Pasteurelia spp., Proteus mirabilis, Proteus vulgaris, Fusobacterium spp., Escherichia coli, Klebsiella spp., Neisseria spp., Salmonella spp., Shigella spp., Clostridium perfringens Haemophilus influenzaother pathogens that accompany chronic and subacute forms of endometritis in cows.

Inactivates penicillin-binding proteins (PSB), which are located on the inner membrane of the bacterial cell wall and participate in the terminal stages of cell wall collection, as well as when it changes during growth and division. Their inactivation prevents the cross-linking of the peptidoglycan chains which are necessary for strength of the cell wall. This weakens the cell wall and leads to the lysis of bacterial cells.

It is resistant to penicillinase and retains activity under aerobic and anaerobic conditions.

After injection into the uterine cavity, it easily penetrates into the endometrium, where it remains in bactericidal concentration for at least 24 hours. At the same time, it practically does not enter the bloodstream and has no systemic effect. Therefore, the maximum concentration in the blood plasma is only 0.11-0.13 µg/ml.

Excreted from the body mainly with the urine in an unchanged form and in the form of a metabolite — desacetylcefapirin, which also has antibacterial activity.



Treatment of cows with chronic and subacute forms of bacterial etiology endometritis.



Do not administer to animals with hypersensitivity to the active ingredients of the drug.

Do not use simultaneously with other intrauterine antibiotics.


Administration and dosage

Before introduction of the drug, sanitize the external genital organs and the root of the tail of the cow. If necessary, the uterus is freed from inflammatory exudate.

The syringe tube is shaken vigorously, connected to the catheter, the cervix is fixed rectally, the catheter is carefully inserted through the cervix into the uterus, and the contents of the syringe tube are squeezed out (19 g).

The manipulation is carried out once and, if necessary, repeated after 7-14 days. Introduction of Dinotrom (or other drugs based on F2α prostaglandins) 3-4 days before the use of Cefmethrin, significantly increases the effectiveness of treatment and eliminates the need to repeat it (especially with pyometra).



Slaughter of cows for meat is allowed after 4 days after the last administration of the drug. Meat obtained before the specifies period, disposed of or fed to unproductive animals, depending on the conclusion of a veterinarian.

Milk of cows can be consumed without restrictions.



Plastic syringe-tubes of 19 g (10 pcs. in a cardboard box, assembled with catheter and gloves).



In a dark dry place, out of reach of children, at the temperature from +2 °С to +25 °С.


Shelf life

2 years.