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Choice of preparations by animal species

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Suitable for:

cow

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tablets for intrauterine use

 

Composition

7.5 g (1 tablet) contains:

sulfadiazine sodium salt — 3975 mg

kanamycin sulfate — 50.25 mg

oxytetracycline hydrochloride — 50.25 mg

 

Description

Light brown, flat tablets of oval-oblong form.

 

Pharmacological properties

Antimicrobial, antiseptic and veterinary preparations for intrauterine use.

Pharmacological properties of the drug are caused by the peculiarities of total interaction of three antibiotic components and excipients complex.

Sulfadiazine, which refers to sulfanilamides, because of its structural similarity to PABA (para-aminobenzoic acid) inhibits the bacterial enzyme responsible for the biosynthesis of dihydrofolic acid that is a precursor of folic acid in the bacterial cell.

Oxytetracycline hydrochloride by inhibiting the activity of ribosomes of bacteria leads to disruption of protein synthesis. Through the formation of chelate compounds with bivalent metal cations, it inhibits a number of metabolic processes in microbial cells.

Kanamycin sulfate belongs to the group of aminoglycoside antibiotics. It penetrates the cell membrane and irreversibly binds to specific receptor proteins on the 30S ribosome subunit. It violates complex formation between matrix (information) RNA and 30S ribosome subunit. As a result, in the cell biosynthesis of defective proteins and polirybosom collapse occur and it loses the ability to synthesize protein. It violates the structure and function of the cytoplasmic membrane, causing a rapid loss of microbial cells.

Auxiliary foaming components provide drug distribution throughout the uterus and complete antibiotic substances contact with mucous membrane.

 

Indications

It is indicted for the prevention and treatment of cows suffering from acute endometritis, metritis, cervicitis and vulvovaginitis caused by A. pyogenes, Streptococcus spp., Staphylococcus aureus, E. coli, Proteus spp., Klebsiella spp. etc., as well as for the rehabilitation of the uterus after the removal of detained litter.

 

Contraindications

Hypersensitivity to the drug.

 

Administration and dosage

Intrauterine administration.

• prophylactically in a dose of 7.5-10 g of drug one time during the first days after calving;

• therapeutically in a dose of 12.5-15 g of drug daily for 2-3 consecutive days.

 

Warning

Hypersensitive animals may have allergic reactions.

Slaughter of animals for meat is allowed in 2 days after the last administration. In the case of slaughter before the specified period the meat can be used for the production of meat- and-bone meal tankage. Milk can be consumed in 2 days after the last administra­tion of the drug. Milk obtained before the specified period can be used for animal feeding after heat treatment.

 

Packaging

Polymer packages of 1 tablet (6 or 8 pcs in a plastic container).

 

Storage

Store in a dry, dark place, out of children reach at the temperature from +4 °C to +25 °C.

 

Shelf life

3 years.