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Choice of preparations by animal species

Brovaseptol for injection

Suitable for:

horse cow goat sheep pig dog cat rabbit

turkey chicken duck goose

Brovaseptol for injection

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Brovaseptol injectable

powder for injection

 

Composition

1 g contains:

sulfadimetoxin sodium salt — 300 mg

sulfadiazine sodium salt — 300 mg

trimethoprim — 120 mg

Includes a vial of sodium chloride 0.9%

 

Description

Homogeneous powder of light-yellow color with light characteristic smell.

 

Pharmacological properties

The combined antibacterial preparation of a wide spectrum of action.

Sulfonamides and trimethoprim (a derivative of diaminopyrimidine) block enzymes in two consecutive stages of the biosynthesis of folic acid in a bacterial cell, which leads to suppression of bacterial growth, cessation of their reproduction and death. The combination of active ingredients in the preparation reduces the likelihood of the emergence of resistant forms of pathogenic microflora.

Acts against Gram-positive and Gram-negative bacteria Staphylococcus spp., Streptococcus spp., Neisseria spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., E. coli, Salmonella spp., Klebsiella spp., Proteus spp., Citrobacter spp., Pasteurella spp., Bordetella spp, Enterobacter spp., Yersinia enterocolitica, Chlamidya spp., Vibrio cholerae etc., some protozoans Pneumocystis carinii, Coccidia, Toxoplasma.

Sulfanilamides are quickly distributed throughout the body, their therapeutic concentration is maintained in serum for 25 hours. Their concentration in kidneys is higher, and in skin, liver and lungs is lower than in blood plasma.

Trimethoprim is rapidly distributed throughout the body, its maximum concentration is reached 4 hours after injection. Concentration in lungs, liver and kidneys is higher than in blood plasma.

Sulfonamides and trimethoprim are excreted by kidneys through glomerular filtration and tubular secretion. A small amount is metabolized in liver and is excreted with bile.

 

Indications

It is indicated for treatment of cattle, sheep, horses, pigs, rabbits, dogs, cats and poultry (chickens, turkeys, geese, ducks) suffering from the diseases of the digestive tract (gastritis, enteritis, dyspepsia), respiratory organs (tonsillitis, tracheitis, pharyngitis, pneumonia, pleurisy) and genitourinary system (puerperal sepsis, cystitis, urethritis, endometritis), postoperative complications, as well as animals suffering from mastitis, actinomycosis, erysipelas, dysentery, diplococcus, enterotoxaemia , eimeriosis, colibacillosis, pasteurellosis, pullorosis, edematous disease, mycoplasmosis, salmonellosis.

 

Contraindications

Hypersensitivity to the drug. Do not administer to animals with renal or hepatic impairment.

 

Administration and dosage

Drug is diluted with sodium chloride solution 0.9%, and administer intramuscularly in the following doses:

• cattle, sheep, horses, pigs — 0.6-0.8 ml per 10 kg of b.w.;

• dogs, cats — 0.1-0.15 ml per 1 kg of b.w.;

• poultry (chickens, turkeys, geese, ducks), rabbits — 0.1 ml per 1 kg of b.w.

For large animals intravenous or intraarterial administration is allowed.

The drug is administered 3-5 times at intervals of 24-36 hours during 5 days. If clinical symptoms remain, the course continues for 2 more days.

Treatment of young poultry, pigs and rabbits can be carried out orally with drinking water. For that to the daily requirement of drinking water is added the drug in a dose of 1 ml per 0.9-1.2 l of water or 1 g of powder per 3 l of water.

Injection over 10 ml (for small and young animals) and 20 ml (for large and mature animals) is divided into two or more parts and injected in different sites.

 

Warning

Do not dilute with novocaine.

Slaughter for meat is allowed in 10 days, milk is allowed to use in food in 10 days.

 

Packaging

Glass vials of 3.3 and 6.6 g (including a sterile bottle of sodium chloride 0.9% of 8 and 16 ml, respectively).

 

Storage

Store in a dark place, out of children reach at the temperature from 0 °C to +25 °C.

Prepared solution should be used within 1 day, or within 3 days provided storage in a fridge.

 

Shelf life

2 years.