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Choice of preparations by animal species

Brovafom new

Suitable for:

cow

sheep pig

rabbit

turkey chicken duck goose dove

Brovafom new

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Brovafom new

powder for oral administration

 

Composition

1 g contains:

colistin sulphate — 500 000 IU

oxytetracycline hydrochloride — 35 mg

trimethoprim — 27 mg

 

Description

Light yellow powder, soluble in water.

 

Pharmacological properties

Complex antimicrobial preparation of a wide spectrum of action.

Oxytetracycline is a bacteriostatic antibiotic, when interacting with ribosomes disrupts protein synthesis and reduces the permeability of the cytoplasmic membrane of microorganisms, acts against gram-positive and gram-negative microorganisms — Streptococcus spp., Clostridium spp., Corynеbacterium spp., Brucella spp., Haemophilus spp., E. coli, Pasteurella spp., Klebsiella spp., Erysipelothrix spp., Fusobacterium spp., Salmonella spp., protozoans, mycoplasma Mycoplasma spp., rikettsiae Rickettsia spp., chlamydia Chlamydia. Forms metabolites in a small amount, from the body is excreted in the urine, bile and milk.

Colistin, an antibiotic from the polymyxin group, acts on the gram-negative microorganisms E. coli, Salmonella spp., Pasteurella spp., Haemophilus spp., Bordetella spp. It binds phospholipid A of cell membranes and neutralizes the effect of endotoxin of bacteria, which leads to destruction of membrane structure. The permeability of the cell membrane changes immediately after contact with the drug. From the gastrointestinal tract is absorbed in a small amount, so high concentrations of the drug are observed in different parts of it. It is excreted from the body by the kidneys in the form of active metabolites.

Trimethoprim acts against Gram-positive bacteria Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., Gram-negative bacteria of E. coli, Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp., Bordetella spp. etc. Blocks protein synthesis in bacteria, inhibits bacterial reductase, which converts dehydrofolic acid to tetrahydrofolic acid, which is necessary for the synthesis of purines and nucleic acids. It binds to blood plasma proteins by 70%, high concentration of trimethoprim is observed in the secretion of bronchial glands, prostate gland and bile. The half-life in blood plasma is 8-10 hours, after 72 hours it is excreted in urine by 66.8%.

 

Indications

It is indicated for treatment of diseases caused by Gram-positive and Gram-negative agents:

pigs: dysentery, colibacillosis, pasteurellosis, salmonellosis, as well as diseases of the digestive tract and respiratory system;

calves and lambs (aged up to six weeks): enteritis, diseases of respiratory system;

rabbits: enteritis, diseases of respiratory system;

poultry (chicken-broilers, replacement chickens, turkeys, peasants, geese, ducks): mycoplasmosis, colibacillosis, pasteurellosis, diseases of respiratory system.

 

Contraindications

Do not administer to animals with hypersensitivity to the drug, with impaired liver and kidney function, to ruminants with functionally developed proventriculus. Do not administer to laying hens, which eggs are used in food.

The drug is incompatible with hydrocortisone, heparin, decenoic acid, cephalosporins, aminoglycosides and amphotericin.

 

Administration and dosage

Oral administration in the following doses:

pigs, poultry (group method) — 1 kg per 1000 l of drinking water, or 1.5-2 kg per 1 ton of mixed feed for 3-5 days;

rabbits — 1 to 1.5 g of drug per 1 l of drinking water for 3-5 days;

calves and lambs (aged up to six weeks), piglets (individually) — 0.5 g per 10 kg of body weight, 2 times a day for 5-7 days.

 

Warning

Slaughter of animals for meat is allowed in 10 days after the last administration of the drug, poultry — in 7 days. Meat obtained before the specified period is utilized or used for feeding non-productive animals.

 

Packaging

Polymer package of 10, 20, 100 g; 1 kg.

 

Storage

Store in a dry dark, unreachable for children place at the temperature from +8 °C to +25 °C.

 

Shelf life

3 years.