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Choice of preparations by animal species

Ftorfenlic 30

Suitable for:

cow

pig

Ftorfenlic 30

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Ftorfenlic 30

solution for injection

 

Composition

1 ml contains:

florfenicol — 300 ml

 

Description

Clear, sterile liquid with a yellowish tint.

 

Pharmacological properties

Florfenicol is a thiamphenicol derivative, where the hydroxyl group is replaced by a fluorine atom. Active against pathogens producing acetyltransferase and resistant to chloramphenicol, it provides bacteriostatic and bactericidal action by binding in the protoplasm of a bacterial cell with the ribosomal subunit of 70S bacteria, blocking enzyme peptidyl transferase, which leads to disruption of amino acid transport and further stopping protein synthesis at the ribosome level in microorganisms.

After parenteral administration, it is rapidly absorbed and penetrates most organs and tissues (lungs, kidneys, muscles, intestines, heart, liver, spleen). The maximum concentration in blood serum is reached after 30-90 minutes, the therapeutic concentration is maintained for a minimum of 48 hours. It is excreted from body in unmodified form and in the form of metabolites mainly with urine, partly with feces.

 

Indications

It is indicated for treatment of cattle and pigs suffering from diseases caused by Gram-positive and Gram-negative microorganisms:

• cattle — infectious respiratory diseases caused by Pasteurella multocida, Klebsiella pneumonia, Streptococcus pneumoniae, Haemophilus somnus, interdigital phlegmons (purulent lesions of hooves, interdigital necrobaciliosis, infectious pododermatitis) caused by Fusobacterium necrophorum and Bacteroides melaninogenicus, as well as in case of infectious keratoconjunctivitis caused by Moraxella bovis;

• pigs — infectious respiratory diseases, especially pleuropneumonia caused by Actinobacillus pleuropneumoniae and/or Haemophilus parasuis, Pasteurella multicida, M. hyopneumoniae, M. hyorhinis and atrophic rhinitis.

 

Contraindications

Hypersensitivity to florfenicol. Do not administer to farrowing sows, heifers in the first third of pregnancy, bulls, breeding boars and lactating animals whose milk is used for food purposes.

 

Administration and dosage

Cattle:

intramuscularly — in the middle of the neck in a dose of 1 ml per 15 kg of body weight, treatment course — injections with an interval of 48 hours;

subcutaneously — 2 ml per 15 ml of body weight, once.

The dose of the drug administered in one injection site should not exceed 10 ml.

Pigs: intramuscularly in the neck in a dose of 1 ml per 20 kg of body weight, twice in 48 hours.

 

Warning

While proper administering and dosage side effects are usually not observed. In some hypersensitive animals redness, swelling near the anal region and soft feces that do not affect the physiological state of the animals may appear which do not require the use of drugs.

Do not use simultaneously with tiamfenicol and chloramphenicol mixing in the same syringe with other drugs, as well as its contact with water. Dry syringes and injectors are used only.

Slaughter of cattle for meat is allowed in 34 days after the last intramuscular administration and in 42 days after subcutaneous one, and the meat of pigs is allowed to use for food purposes in 21 days after the last administration.

In the case of slaughter before the specified period the meat is utilized or fed to unproductive animals, depending on the conclusion of a veterinarian.

 

Packaging

Dark glass vials of 50, 100 (1 pc in a cardboard box).

 

Storage

Store in a dry, dark place, away from children at the temperature from +5 °C to +25 °C.

 

Shelf life

2 years.